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Detailed visualisation of the interactions of the target protein with proprietary compounds is critical to guide and accelerate the optimisation of these compounds and progress them to drug candidates.
低温电子显微镜 works by flash-freezing - fast enough to stop the water present forming ice crystals - a microscopic protein sample in a single-molecule-thick layer of vitreous ice. 使用电子束, hundreds of thousands of images of individual molecules within the sample are captured from multiple viewpoints, allowing the computational construction of an exquisitely detailed 3D model. These atomic resolution models even help reveal how structures within the molecules move and change as they perform their functions.
在澳门葡京网赌游戏, cryo-EM has already enabled the identification of a number of world-first protein structures all of which are telling us new information about a range of targets and drug candidates we are working on:
结构生物学团队的发现科学,R&D at AstraZeneca has access to two state-of-the-art cryo-electron microscopes through the 剑桥 Pharmaceutical 低温电子显微镜 Consortium, 与剑桥大学的合作, LMB实验室的, leading manufacturer Thermo Fisher and four other pharmaceutical companies in the 剑桥 area. This Consortium allows us to not only access the very highest-level technology but facilitates our culture of keeping doors and minds open so we can achieve all we want to achieve in pushing the boundaries of science to deliver life-changing medicines. 在瑞典, AstraZeneca’s collaboration with SciLifeLab at Stockholm University and the Karolinska Institutet has provided similar benefits.
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